Diabetes often goes undiagnosed because many of its symptoms seem so harmless. Recent studies indicate that the early detection of diabetes symptoms and treatment can decrease the chance of developing the complications of diabetes. Some diabetes symptoms include:
So if migraines are disrupting your life, ask your doctor about prescription IMITREX. It was specifically made to target the nerves and blood vessels that are believed to trigger your total migraine – the pain, nausea,sensitivity to light and sound – so you get the relief you need, without drowsiness.
Tension headaches are caused by stress, muscular tension, vascular dilation, postural changes, protracted coughing or sneezing, and fever. Physical and mental conditions that can lead to chronic muscular tension and headache include:
* Anxiety * Arthritis in neck or spine * Degenerative bone or disk disease in the neck or spine * Depression * Temporomandibular joint disorders
There are several well-known triggers associated with cluster headaches, including drugs that dilate or constrict blood vessels and alcohol. This suggests that changes in the walls of blood vessels in the head may be partly responsible.
Some researchers believe that a low level of endorphins may cause frequent, severe, or chronic headache pain. Endorphins are painkilling compounds found in the brain.
New data show that Imitrex Tablets formulated with RT Technology disintegrated six times faster and were absorbed more quickly than conventional Imitrex Tablets. The findings of this study were presented at the 47th Annual American Headache Society Scientific Meeting in Philadelphia last month...
The four-way cross-over pharmacokinetic study of five migraine sufferers compared Imitrex Tablets formulated with RT Technology with conventional Imitrex Tablets. Patients were given a 100-mg radio-labeled tablet with radio-labeled water outside of a migraine attack. Images of the gastrointestinal tract were taken via gamma scintigraphy every minute for the first 30 minutes and every 10 to 15 minutes for four hours. Endpoints were time to disintegration, gastric emptying, and time to onset of absorption.
Results from the study showed that the mean time to disintegration was six times faster with Imitrex Tablets, formulated with RT Technology, (6.2 minutes vs 38.8 minutes) compared to conventional Imitrex Tablets. The mean time to 50 percent gastric emptying was about 30 minutes faster, and at 20 minutes, plasma levels were more than five times higher than conventional Imitrex Tablets.
Imitrex Tablets, formulated with RT Technology, are bioequivalent to conventional Imitrex Tablets as measured by AUC0-24 and Cmax. The clinical significance of the scintigraphy data is unknown.
“We conducted this study to evaluate if the tablet formulated with RT Technology could deliver faster disintegration and absorption,” said Shashidhar Kori, MD, director of clinical development, Neurosciences Medicine Development Center, North America, GlaxoSmithKline, who presented the study findings. “These findings are important because they provide insight into how this delivery technology works in the gastrointestinal tract.”
Imitrex Tablets, formulated with RT Technology, are designed to enhance the dispersion and dissolution of the active ingredient sumatriptan, even in the presence of gastric stasis. Gastric stasis can delay the disintegration of drugs in the stomach, causing slower absorption of the medication into the bloodstream.
“In my experience, many migraineurs prefer oral therapy to treat their migraines,” said Sheena Aurora MD, director of the Swedish Headache Center in Seattle, Wash. “However, gastric stasis, a common occurrence in migraine patients, has the potential to limit the efficacy of medicine that is swallowed. Therefore research to identify innovative ways to deliver migraine medication is crucial.”
These findings are consistent with earlier studies of Imitrex Tablets, formulated with RT Technology. In vitro dissolution studies have shown Imitrex Tablets formulated with RT Technology dissolve five times faster than conventional Imitrex tablets. The clinical significance of the in vitro dissolution data is unknown.
Imitrex is used to treat migraine headache attacks once they occur. It is not effective in preventing migraines. Imitrex is not to be used for other types of headaches.
One dose is taken by mouth at the first signs of a migraine attack. If you must take a second dose, do so exactly as instructed by your doctor. Do not take more than 200mg in a 24 hour period. Tablets are to be swallowed whole with a glass of water. Do not crush or chew them.
Tell your doctor if you have: heart disease, coronary artery disease, high blood pressure, stroke, kidney disease, liver disease, allergies (especially drug allergies). There have been rare reports of those with sulfa drug allergies having allergic reactions to sumatriptan. Consult your doctor or pharmacist. Since Imitrex may cause drowsiness, use caution operating machinery or engaging in activities requiring alertness and avoid alcohol because it may increase drowsiness/dizziness effects. The manufacturer does not recommend use of sumatriptan in the elderly, because they may be more sensitive to its side effects. Sumatriptan should be used during pregnancy only when clearly needed. Discuss the risks and benefits with your doctor. Imitrex is excreted into breast milk. The effects on nursing infants are unknown at this time. Consult your doctor before breast-feeding.
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